CCN2 and bronchopulmonary dysplasia: CTGF is thought to play an important role in hyperoxia-induced lung changes as its gene and protein expression are greatly increased by hyperoxia exposure and in a hyperoxia-induced BPD with PH model in newborn rats, inhibition of CTGF activity by a CTGF neutralizing antibody drastically decreased PH by improving vascular development and reducing vascular remodeling [18].