Microglial cells pretreated with different concentrations of WT TIDM and mTIDM peptides for 1 hour were stimulated with fibrillar Aβ1-42 (an etiological reagent of AD), 1-methyl-4-phenylpyridinium (MPP+) (Parkinsonian toxin), lipoteichoic acid (LTA) (agonist of TLR2), poly IC (agonist of TLR3), LPS (agonist of TLR4), flagellin (agonist of TLR5), or CpG DNA (agonist of TLR9). This evidence concerns the gene TLR3 and Alzheimer disease.