To investigate the role of TLR2 in the pathogenesis of AD, we monitored the level of TLR2 by immunoblot analysis of prefrontal cortex (PFC) (Brodmann area 9) cells from 33 subjects who died with AD dementia (n = 10) or mild cognitive impairment (MCI) (n = 11) and from age-matched individuals with no cognitive impairment (NCI) (n = 12) (Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/JCI96209DS1). This evidence concerns the gene TLR2 and Cognitive impairment.