High TROP-2 expression is also correlated with increased metastasis in patients with different cancer types (oral squamous, thyroid, some esophageal, gastric, colorectal, pancreatic, ovarian, uterine, cervical, prostate, and urinary bladder), but is not upregulated in others (e.g., head and neck and certain lung cancers, such as lung adenosquamous and squamous cell carcinoma histology) (reviewed by [9, 37, 38, 58]). Here, TACSTD2 is linked to cancer.