In the RNA sequencing data genes linked to arteries (Elastin, Lamb1, Acta2), pericytes (Cspg4/Ng2, Pdgfrb, Sca1 (Ly6a)) and neurons/neurites (Gap43, Tubb3) were up-regulated in the stroma of osteolytic bone metastasis, (Figure 4A). This evidence concerns the gene LY6S and metastasis.