ECM-receptor interaction, axon guidance, focal adhesion, hedgehog/Tgfβ/Wnt signaling pathways and cardiomyopathy were significantly enriched pathways (p value ≤ 0.05) in the up-regulated stroma genes common to PC-3 and MDA-MB231 xenografts (Figure 2A). This evidence concerns the gene TGFB1 and cardiomyopathy.