MAPT and Cognitive impairment: These findings are incongruent with previous findings in individuals with MCI as well as in cognitively normal individuals showing that tau and other neurodegenerative features, rather than Aβ, are associated with cognitive impairment and decline in various cognitive domains (Nelson et al., 2012; Mormino et al., 2014; Pettigrew et al., 2015; Brier et al., 2016; Degerman Gunnarsson et al., 2016; Dumurgier et al., 2017; Cerami et al., 2018).