ZIC5 and hepatocellular carcinoma: Briefly, this integrated analysis of genomewide DNA methylation and gene expression data identified a group of novel gene signatures (ALX3, B4GALNT1, CTHRC1, DLX5, EMX1, IRX3, OTX1, SIX2, TLX1, VASH2, ZIC2, ZIC4, ZIC5, and ZNF695), which may be regulated by DNA methylation in HCC.