SMAD3 and coronary artery disorder: The RHOA gene itself was identified as a genome-wide significant locus in the latest CARDIoGRAMplusC4D meta-analysis (15) and is predicted to interact with several other CAD genes/pathways in smooth muscle cells and endothelial cells including TGFβ/SMAD3 and ECM proteins, such as collagens and fibronectin (36).