Genetic studies have identified variations in the HMGCR gene (rs12916) consistently associated with both blood lipids and LDL-cholesterol (52, 53), while an intergenic variant near HMGCR is also associated with CAD in the combined CARDIoGRAMplusC4D and UK Biobank analysis (20). This evidence concerns the gene HMGCR and coronary artery disorder.