Furthermore, we found the frequency of MDSCs was negatively correlated with the expression of WT-1 and nephrin in pristane- or imiquimod-induced lupus-like model mice, which has been demonstrated the correlation with nephrotic-range proteinuria and extensive effacement of podocyte foot processes in LN (17, 36). The gene discussed is NPHS1; the disease is systemic lupus erythematosus.