Comparison of genotypes and allele frequencies of all the SNPs between multibacillary and paucibacillary TB revealed that the genotype 1805TT TLR1 (rs5743618) was prevalent among paucibacillary patients (OR = 0.38; 95% CI = 0.19–0.76; p = 0.009) while the genotype 1805TG was common among multibacillary patients (OR = 3.72; CI = 1.65–8.4; p = 0.004). This evidence concerns the gene TLR1 and tuberculosis.