In this study, we investigated whether the SNPs rs5743618 (1805T/G) of TLR1, rs5743708 (2258G/A) of TLR2, rs4986790 (896A/G) and rs4986791 (1196C/T) of TLR4, rs5743810 (745C/T) of TLR6, and the rs5743836 (−1237A/G) and rs187084 (−1486A/G) of TLR9 are associated with TB and with the bacterial load. This evidence concerns the gene TLR4 and tuberculosis.