SLE is characterized with a high level of autoantibody in serum (1); tissue IgG deposition is associated with skin and kidney damage (18); intrahepatic injection of lupus IgG induced liver inflammation; and liver inflammation induced by lupus IgG was reduced in FcγRIII-deficient mice, but increased in FcγRIIb-deficient mice. This evidence concerns the gene FCGR2B and systemic lupus erythematosus.