NFKB1 and endothelial dysfunction: Previous study Chiva-Blanch et al. (2016) demonstrated a higher percentage of serum oleic acid in acute myocardial infarction patients, and the elevated plasma oleic acid may cause endothelial dysfunction and atherosclerosis through sequential activation of protein kinase C (PKC) and NF-κB-dependent signaling pathways, which showed a highly correlation with inflammation (Park et al., 2003).