Although specific neuropathology biomarkers, such as the detection of Aβ and tau accumulation measured by PET imaging (James et al., 2015; Dubois et al., 2016) and in CSF (Bateman et al., 2012; Fagan et al., 2014) can be detected predates the onset of clinical symptoms and have shown high specificity in confirming AD pathophysiology (Beckett et al., 2010; Dubois et al., 2014), the high cost, narrow isotope availability of PET probes and invasive characteristics of CSF biomarkers limited their broad usages. This evidence concerns the gene MAPT and Alzheimer disease.