As discussed by Mueller and Dieplinger (59), plasma concentrations of these two analytes have been incorporated in 2013 ACCF/AHA guidelines for additive risk stratification in acute and chronic heart failure (60) and Gal-3, sST2 and BNP were all useful as predictors of 1-year all-cause mortality (6). Here, LGALS3 is linked to congestive heart failure.