That is, we and several other groups have previously demonstrated that UCP2, which mRNA was found nearly ubiquitously (Fleury et al., 1997; Alan et al., 2009), is present at protein level exclusively in highly proliferating cells, which have a glycolytic type of metabolism, such as cancer, stem and activated immune cells (Pecqueur et al., 2001; Alves-Guerra et al., 2003; Zhang et al., 2011; Rupprecht et al., 2012, 2014; Yu et al., 2013). This evidence concerns the gene UCP2 and cancer.