Similar IL-37-mediated anti-allergic inflammatory activities, such as the suppression of inflammatory cytokine/chemokine expression, specific IgE, inflammatory cell infiltration, thickened airway wall, collagen deposition, mucus and lung fibrosis together with upregulated Treg in lung tissue, etc., were shown in OVA-induced allergic asthmatic mice (Figure S4 in Supplementary Material) and HDM-induced allergic asthmatic mice (Figure S5 in Supplementary Material). Here, IL37 is linked to pulmonary fibrosis.