TLR2 and infection: In our study, BEAS-2B cells, which share similar pattern for the expression of cell surface adhesion molecules and production of inflammatory cytokines and chemokines with primary human bronchial epithelial cells as demonstrated in our previous studies (49, 50), were used to coculture with human eosinophils followed by stimulation with TLR2 ligand PGN to mimic the microenvironment upon infection in the bronchus of allergic asthmatic patients.