Cytokines and chemokines released by Th2 cells (IL-4, IL-5, IL-6, IL-9, IL-10, and IL-13) and those induced by other cell types in response to Th2 cytokines (CCL11, transforming growth factor/TGF-β, and IL-11) mediate most of the pathophysiological mechanisms in allergic reaction such as the recruitment, activation, and delayed apoptosis of eosinophils, and degranulation to release granular toxic proteins from eosinophils (11). The gene discussed is IL13; the disease is allergic disease.