In an attempt to further evaluate the anti-inflammatory mechanism of IL-37 in allergic asthma, in vitro intracellular signaling mechanisms of TLR2-activated human eosinophils and the in vivo immunoregulatory activities of IL-37 in house dust mite (HDM)-humanized allergic asthmatic mice, ovalbumin (OVA)/HDM-induced allergic asthmatic mice have been investigated. Here, IL37 is linked to allergic asthma.