In two samples, there was a genetic discrepancy between KIRs and HLA on the primary MM cells enabling us to subgroup NK cells based on the KIR–ligand matched/mismatched status and to investigate whether KIR–ligand interaction played a bigger role than NKG2A–HLA-E interaction in inhibiting NK cells activity. The gene discussed is KLRC1; the disease is Miyoshi myopathy.