Since the IL-2-activated NK cell ex vivo expansion protocols could result in a higher percentage of NKG2A expressing NK cells (19, 20), we performed, in the current study, an in-depth analysis of the influence of NKG2A expression on different NK cell subsets in response to MM cells showing that the inhibitory potential of NKG2A, for activated NK cells, depends on the exact subset of NK cells and the HLA-E context of the target cell. Here, HLA-E is linked to Miyoshi myopathy.