Insulin is another proposed mediator between frailty and cognition, considering insulin resistance with age.47 Vitamin D, also has a correlation with frailty and cognition, with low levels of vitamin D indicating cognitive impairment, lower processing of the information and decreased physical functioning.42 Nutrition can present a link between cognition and frailty due to biological and behavioral effects and, cardiovascular risk may be another factor between frailty and cognition. Here, INS is linked to Insulin resistance.