To search for partners synthetically lethal with HK2 silencing in HK1−HK2+ cancer cells, 119 FDA-approved oncology drugs and 3205 drug-like compounds were screened, with or without DOX-induced shHK2 HK2 knockdown, in Hep3B/shHK2dox cells (Fig. 3a, Additional file 2: Table S1). Here, HK2 is linked to cancer.