While shHK2, DPI, or PER had no significant effect on xenograft HK1+HK2+ shHK2DOX H460 tumor growth, shHK2 alone reduced tumor volume by 47%, and the shHK2/DPI/PER combination reduced tumor volume by 69% in HK1KOHK2+ shHK2DOX H460 tumors (Fig. 7c). The gene discussed is HK2; the disease is neoplasm.