However, HK1+HK2+ cancer cell lines from a variety of cancers (liver, breast, colon, prostate, ovary, lung), including the lung cancer H460 cell line, are resistant to HK2 silencing alone (Fig. 2a–d) or the synthetic lethality of the shHK2/DPI/PER (Additional file 1: Figure S5C). The gene discussed is HK2; the disease is cancer.