The combination of shRNA HK2 knockdown and daily DPI i.p. injection at 2 mg/kg did not cause HK1−HK2+ liver tumor cell apoptosis (Fig. 6d), suggesting that DPI at this dosage, in combination with HK2 knockdown, is not sufficient to cause lethality of HK1−HK2+ tumor cells in vivo. This evidence concerns the gene HK2 and neoplasm.