HK2 and neoplasm: In mouse subcutaneous Hep3B/shHK2DOX tumor xenografts, HK2 knockdown by a 4-day DOX treatment in the diet reduced tumor glucose consumption as determined non-invasively by 18F-fluorodeoxyglucose (FDG)/positron emission tomography (PET) imaging [18, 19] (Fig. 2g, h).