The combination shHK2/DPI treatment resulted in increased levels of phosphorylated AMPKα and dephosphorylation of S6 and 4EBP1 in xenograft Hep3B/shHK2DOX tumors (Fig. 3j), demonstrating the reduction in tumor energy production induced by the shHK2/DPI combination therapy. Here, EIF4EBP1 is linked to neoplasm.