PRF1 and Huntington disease: Although we did not observe differences NKp46 and NKG2D expression in the CD56brightCD16lo/−, CD56brightCD16hi, and CD56dimCD16hi subpopulations of NK cells between HD and the CD25-deficient patient (not shown), the three NK cell subpopulations from the CD25-deficient patient contained higher amounts of perforin (Figure 2A) and granzyme B (Figure 2B) compared to HD.