INS and Hyperglycemia: Different experimental and meta-analysis studies have investigated the association of WFS1 variants located at this haplotype (rs10010131, and rs6446482) with the risk of T2DM and many lines of evidence indicate that polymorphisms of WFS1 had important effects on insulin secretion, insulin sensitivity and the risk of hyperglycemia in T2DM which need to be confirmed in different functional analysis studies (29-31).