SERPINE1 and esophageal squamous cell carcinoma: When we used tiplaxtinin, a specific inhibitor of PAI-1, together with cisplatin could inhibit the growth of ESCC cells and induce the apoptosis compared with cisplatin alone (Supplementary Figure 3A and B).These results suggest that PAI-1 secreted by CAFCIS enhances survival and promotes chemoresistance of ESCC cells.