SERPINE1 and neoplasm: To investigate the clinical significance of PAI-1 in patients’ tumor tissues, we evaluated the correlation between PAI-1 expression in CAFs and clinicopathological characteristics of patients (Supplementary Table 1) and found that patients with high expression of PAI-1 in CAFs presented a significantly worse progression-free survival (PFS) after cisplatin chemotherapy (Fig. 7a, b).