In fact, CD8+ T-cell infiltrates are generally associated with better prognosis while CD4+ T cells, which include T-regulatory cells, have been associated with worse outcomes.8 Immunohistochemical analysis of tissue microarrays derived from 179 treatment-naive breast tumours revealed that high levels of CD4+ T cells correlated with reduced overall survival (OS), while high levels of CD8+ T cells combined with low levels of CD4+ T cells correlated with increased OS.52 This evidence concerns the gene CD8A and breast neoplasm.