Recently, genomic structural rearrangements of AR (AR-GSRs) were established as a new class of AR gene alteration occurring in one third of CRPC-stage specimens.31 This work showed that the presence of AR-GSRs at high variant allele frequency was associated with outlier, tumour-specific expression of rearrangement-dependent AR-V species that displayed androgen-independent and enzalutamide-resistant transcriptional activity. The gene discussed is AR; the disease is neoplasm.