Furthermore, strong expression of only one of these proteins (ERK or p38MAPK) could be used as a predictive biomarker for clinical trials in BRAF mutant cMMR CRC patients, establishing the benefit of treatment with an agonist to the other member (ERK for p38MAPK agonist and p38MAPK for ERK agonist). The gene discussed is BRAF; the disease is colorectal carcinoma.