ADIPOR1 and Anxiety: To determine if VTA adiponectin action on anxiety-like behavior is mediated via activation of AdipoR1 on dopamine neurons, we assessed the behavioral effects of bilateral intra-VTA infusion of adiponectin in AdipoR1flox/flox/DATIREScre mice vs. AdipoR1flox/flox control mice in the elevated plus maze test.