ADAM17 and Alzheimer disease: The ADAM17 variant (NM_003183:exon6:c.G644T:p.R215I; rs142946965) was the only variant in an AD relevant gene predicted pathogenic by 7 out of 8 prediction programs (SIFT, Polyphen (HDIV/HVAR)), LRT, MutationTaster, Provean and FATHMM), conserved by three out of four conservation scores (DAMN, GERP, SiPHy) and additionally located within the maximal LOD score region of the pedigree.