APP and Alzheimer disease: Table 2) showed a very strong negative correlation (p = 2.2×10−16, r2 = 0.55 for the average of APP markers ILMN_2404065, ILMN_2404063, and ILMN_1653283 compared to the average of ADAM17 markers ILMN_1765779 and ILMN_2121068) of ADAM17 and APP mRNA both, in AD and control brains (Fig. 4a).