GPNMB and cancer: Further analyses confirmed that AA6 repressed, both at mRNA and protein level, extracellular matrix proteases (e.g. Mmp3), cell adhesion molecules (e.g. Gpnmb), and transcription factors associated to cancer progression (e.g. Ctbp1) with a minor effect on cell proliferation genes (e.g. Plaur and Src) (Fig. 2b, c).