AKT (Ser473) phosphorylation was increased when CD45+CD33lowCD11bdim myeloid cells were stimulated with rhIL-6 and rhIL-8 (Fig. 4d), and decreased following the addition of neutralizing anti-IL-6 and IL-8 Abs to 50% GC patient serum (Fig. 4d). The gene discussed is AKT1; the disease is gastric cancer.