Further immunoprecipitation with RUNX2 on lysates of MSCs (C3H10T1/2) differentiated with normal (5.5 mM) vs high (25 mM) glucose blots probed with p-AMPK substrate motif-specific antibody suggested that AMPK-mediated RUNX2-S118 phosphorylation is the key modulator of differentiation process during diabetes (Fig. 4g). The gene discussed is RUNX2; the disease is diabetes mellitus.