Despite functioning in the liver, we identified multiple promoter interactions between SORT1 and the myocardial infarction GWAS locus in CMs (Figure 7D), directly implicating SORT1 as the target gene and lending further support to experimental validation of this locus as a SORT1 enhancer (Musunuru et al., 2010). This evidence concerns the gene SORT1 and myocardial infarction.