Increased CRH expression in AD parventricular nucleus has been associated with hyperactivity of the hypothalamic–pituitary–adrenal axis that may underlie the elevation of opioidergic peptide synthesis, as observed in the transgenic TASTPM mice (Raadsheer et al., 1995; Scherder et al., 2003). The gene discussed is CRH; the disease is Alzheimer disease.