In this context, it is noteworthy that PLAT and NRP1 play a well‐documented role in angiogenesis, in line with previous reports about a putative angiogenic function of IL6 in BCC.45, 46, 47 However, as we did not detect a decrease in CD31+ endothelial cells in Il6ra‐deficient mouse BCC (data not shown), it appears rather unlikely that HH‐IL6 signal integration drives BCC growth by supporting tumor angiogenesis. Here, PECAM1 is linked to skin basal cell carcinoma.