Although genetic and epigenetic alterations within cancer cells are the main drivers of malignant development, it has recently become clear that intricate reciprocal interactions of cancer cells with the tumor microenvironment and the immune system are pivotal for malignant progression.18 In this study, we performed a candidate‐based screen for immune‐related modifiers of oncogenic HH/GLI signaling and identified a striking tumor promoting role of the proinflammatory cytokine IL6 in HH/GLI‐driven oncogenic transformation and BCC development. This evidence concerns the gene IL6 and skin basal cell carcinoma.