PTCH1 and neoplasm: For this purpose, we crossed Keratin14creERT;Ptchfl/fl (PtchΔep) mice, which develop BCC lesions upon tamoxifen (TAM)‐induced, epidermal‐specific Ptch deletion,37 with mice harboring a conditional, floxed Il6ra allele (Il6rafl/fl)38 to generate BCC mice with an additional tumor‐specific deletion of Il6ra (PtchΔep;Il6raΔep) (Fig. 4b).