Indeed, we have previously shown that activation of GLI2 enhances the expression of IL6 in epidermal cells.26 Also, GLI1 has been shown to directly induce IL6 expression in stromal cells of pancreatic adenocarcinoma lesions, triggering paracrine STAT3 activation in the tumor cell compartment.49 Whether IL6 signaling is activated by oncogenic HH/GLI within the tumor cell compartment or communicated to BCC via the tumor microenvironment, infiltrating immune cells or via sIL6R‐mediated trans‐signaling remains to be addressed in future studies. Here, GLI2 is linked to pancreatic adenocarcinoma.