Moreover, blockade of IL-33 attenuates ear swelling in allergic contact dermatitis (ACD), a murine model of AD, but not the sensitization with oxa, suggesting initially upregulated IL-33 is secreted as alarmin without functioning in the sensitization stage, then IL-33 sustains chronic inflammation for the up-regulated TNF-α and IFN-γ [84]. Here, IL33 is linked to allergic contact dermatitis.