On the other hand, miR-663 expression was upregulated in castration-resistant prostate cancer tissues, and miR-663 overexpression in LNCaP prostate cancer cells increased their potentials for proliferation, invasion and neuroendocrine differentiation, while reducing dihydrotestosterone-induced upregulation of prostate-specific antigen expression. This evidence concerns the gene KLK3 and Familial prostate cancer.