BBC3 and non-small cell lung carcinoma: Accordingly, miR-663 proved deleterious in non-small cell lung cancer cells by targeting PUMA/BBC3 (p53 up-regulated modulator of apoptosis/Bcl-2 binding component 3) and BTG2 (B-cell translocation gene 2) transcripts, thus allowing cancer cells to escape apoptosis and promoting tumor onset and development [59].