To confirm the role of ATE1 in the degradation of CTFs of TDP43, we compared the steady-state levels of TDP43219 and TDP43247 in the presence and absence of ATE1 in yeast (Saccharomyces cerevisiae) as well as in a murine neuroblastoma cell line (N2a). The gene discussed is TARDBP; the disease is neuroblastoma.