For example, related to these efforts, the Cutaneous Neurofibroma Subgroup of the Response Endpoints in Neurofibromatosis and Schwannomatosis (REiNS) International Collaboration launched in order to formally develop and evaluate endpoints for clinical trials focused on cNF (ccrod.cancer.gov/confluence/display/REINS/Cutaneous+Neurofibromas). This evidence concerns the gene NPHS1 and schwannomatosis.