This was parallel to the normalization in the expression of the macrophage markers F480 and CD68 and of the pro‐inflammatory cytokines TNF‐α and IL‐1β (Fig 2F–H and Appendix Fig S2C–E), indicating that FGF21 expression counteracted the inflammation of WAT associated with obesity. The gene discussed is FGF21; the disease is obesity due to melanocortin 4 receptor deficiency.