Animals treated with AAV8‐hAAT‐FGF21 vectors were protected from HFD‐induced development of liver neoplasms: 0% (0/8) of animals treated with the 5 × 1010 vg of FGF21‐encoding vectors showed tumors, and the incidence was 40% (4/10) in the cohort treated with the lowest dose (1 × 1010 vg). This evidence concerns the gene FGF21 and Neoplasm of the liver.