Nonetheless, on the mRNA level, the pathway regulating PGC1α (peroxisome proliferator-activated receptor-γ coactivator-1α) is inactivated in PD-patient derived midbrain neurons, which was previously reported to be involved in disease-specific phenotypes in an A53T model of PD [53] and is a hallmark of PD pathology [67]. The gene discussed is PPARGC1A; the disease is Parkinson disease.