Analysing these alterations in neuronal cells on the single gene level, genes that belong to the WNT-pathway were deregulated, i.e. WNT3 was upregulated in PD-patient derived neurons (two-sided Mann-Whitney test, p < 0.05, n = 8 CTRL neurons and 7 PD neurons, Fig. 2c). This evidence concerns the gene WNT3 and Parkinson disease.