Furthermore, in H1299 (NRAS-mut lung adenocarcinoma), in which combined treatment was clearly synergistic (CI: 0.13), enforced expression of different KRAS isoforms (G12C, G12D, G12V) did not substantially modify the nature of pharmacologic interactions between dabrafenib and trametinib, which remained synergistic in all KRAS-mut clones, although to a slightly lesser extent in H1299 V9 (KRASG12V, CI: 0.73, Fig. 6). Here, KRAS is linked to lung adenocarcinoma.