BRAF and cancer: Aberrant activation of the MAPK pathway has been implicated in the pathogenesis of many human diseases, including cancer, in which MAPK activation may stem from either genetic aberrations targeting RAS, B Rapidly Accelerated Fibrosarcoma (BRAF), or Mitogen-activated protein kinase kinase (MEK) directly or dysregulation of upstream acting Receptor Tyrosine Kinases (RTK) [2, 3].