A recent study by Wang et al. detected tumor at the excision surface with 89% sensitivity and 92% specificity by using gold nanoparticles functionalized with reporter SERS labels and monoclonal antibodies targeting biomarkers including epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), estrogen receptor (ER), or CD44 [35]. Here, ESR1 is linked to neoplasm.