MAPT and Cognitive impairment: Furthermore, the GWAS signal set associated with rs6687758 has 50 more variants mostly localized in a long intergenic region and with suggestive cis regulation of the neighboring genes DUSP10, HHIPL2 and FAM177B. If involved, DUSP10 may influence the accumulation of hyperphosphorylated tau, gliosis and synaptic/cognitive deficits due to the uncontrolled, hyperactivation of p38 and JNK kinases.