However, neither PDBu nor HGF were shown to upregulate N-WASP expression in cortactin-knockdown or miR-182 overexpressed lung cancer cells (Fig. 6b).The cell division cycle protein Cdc42, as a member of the Rho GTPase family, plays an important role in actin polymerization, and was necessary for WASP/N-WASP activation [33]. This evidence concerns the gene WASL and lung cancer.