CTTN and metastatic malignant neoplasm in the lymph nodes: As shown in Fig. 1d, the mean expression of cortactin was significantly higher in the group of patients with lymph node metastases (42/55 cases) compared to those without lymph node metastases (13/55 cases) (Wilcoxon two-sample test, rs = 0.1076, P = 0.0165).