In this study, we found that the frequency of T<sub>SCM</sub> and T<sub>CM</sub> cells in the CD8+ population dramatically decreased together with increases in T<sub>EM</sub> and T<sub>EF</sub> cells, particularly in younger patients with acute myeloid leukemia (AML) (< 60 years). Here, CD8A is linked to acute myeloid leukemia.