Moreover, 6 patients in our series had pathogenic variations in genes associated with both syndromic and non-syndromic HL: CDH23 (Usher syndrome 1D and DFNB12), ACTG1 (Baraitser-Winter syndrome type 2 and DFNA20/DFNA26), BSND (Bartter syndrome type IV and DNFB73) or SLC26A4 (Pendred syndrome and DFNB4) (Table 2). This evidence concerns the gene CDH23 and Hodgkins lymphoma.