SMAD7 and colorectal carcinoma: With covariate adjustment, three SNPs in the TGF-β pathway (rs17025857 and rs13075948 in the TGFBR2 gene, and rs11874392 in the SMAD7 gene) were associated with CRC; one of these (rs11874392) is also in the WNT pathway, but no other SNPs in the WNT pathway were associated with CRC after covariate adjustment.