A number of existing drugs and natural compounds inhibit or modulate the JAK/STAT3 pathways, including resveratrol [8,9] and ruxolitinib, an FDA approved drug for the treatment of myelofibrosis (MF), post-polycythemia vera myelofibrosis (PPV-MF), and post-essential thrombocythemia myelofibrosis [10,11]. Here, STAT3 is linked to myelofibrosis.