INSR and cancer: Enrichment analysis displayed that some signaling pathways showed remarkable changes in MKN45/R cells, which are correlated with cancer metastasis, invasion and drug resistance, with main interaction nodes formed by components of Wnt/β-catenin (p = 1.10 × 10−11), insulin receptor (p = 2.68 × 10−7), interleukin-17 (p = 2.46 × 10−9), Notch (p = 1.56 × 10−6), Toll like receptor cascades (p = 1.85 × 10−7), MAPK cascades (p = 7.18 × 10−6), TGF-β (p = 7.74 × 10−6), angiogenesis cascades (p = 3.94 × 10−9), and focal adhesion (p = 8.14 × 10−4) signaling pathways (Figure 3e).