HSPD1 and atherosclerosis: Since the ability of the immune system to generate this potentially dangerous immune response depends not only on the strength of the HSP60 immuno response, which is elevated in patients with periodontitis, but also on the highly polymorphic MHC class I and II epitopes, that are expressed on the cells’ surface, individuals differ with respect to their susceptibility to HSP60-induced atherosclerosis [88].