In the present study, we found that this lack of benefit from EX in TAC is accompanied by EX-induced worsening of eNOS uncoupling (evidenced by eNOS S-glutathionylation and eNOS monomerization), as well as EX-induced reduction of SOD activity, leading to increased eNOS-mediated oxidative stress. Here, NOS3 is linked to persistent truncus arteriosus.