KPNA5 and type 2 diabetes mellitus: Using transcription factor analysis (63), we noted that four of these genes (GRB14, HOMER1, KPNA5 and SLC16A10) had HNF1A type binding sites (Z-score = 9.3); HNF1A occurs at a GWAS risk loci for T2DM (71) and loss-of-function of HNF1A is related to familial early-onset diabetes (130).